Dalbavancin (Xydalba)
نویسندگان
چکیده

 CADTH reimbursement reviews are comprehensive assessments of the clinical effectiveness and cost-effectiveness, as well patient clinician perspectives, a drug or class.
 The inform non-binding recommendations that help guide decisions Canada's federal, provincial, territorial governments, with exception Quebec.
 This review assesses Dalbavancin (Xydalba) for injection, 500 mg (as dalbavancin hydrochloride) per vial, lyophilized powder solution, IV infusion.
 Indication: Treatment adults acute bacterial skin structure infections caused by susceptible isolates following gram-positive micro-organisms: Staphylococcus aureus (including methicillin-susceptible methicillin-resistant strains), Streptococcus pyogenes, agalactiae, dysgalactiae, anginosus group anginosus, intermedius, constellatus), Enterococcus faecalis (vancomycin-susceptible strains).
منابع مشابه
Dalbavancin: a novel antimicrobial
The increasing incidence of serious infections because of Gram-positive pathogens and the rising cost in parenteral administration of antimicrobials has inspired the development of a novel antibiotic. Dalbavancin is the first once a week antibiotic with activity against a broad range of Gram-positive pathogens. A large multicentre, pivotal, Phase III clinical trial, which included 854 patients ...
متن کاملDalbavancin: a novel once-weekly lipoglycopeptide antibiotic.
The increasing prevalence of drug-resistant gram-positive cocci, such as methicillin-resistant Staphylococcus aureus, has underscored the need for new agents for the treatment of this type of infection. Dalbavancin, a new lipoglycopeptide, has the desirable characteristics of increased in vitro activity, compared with vancomycin, for most gram-positive pathogenic bacteria, as well as an extreme...
متن کاملDalbavancin or oritavancin for skin infections.
To the Editor: Boucher et al. (June 5 issue)1 report the results of DISCOVER 1 and DISCOVER 2, and in the same issue Corey et al.2 report the results of SOLO I. These randomized trials investigated the efficacy of oritavancin and dalbavancin in acute bacterial skin and skin-structure infections. We are concerned that the design of these studies and that of other pivotal studies are not consiste...
متن کاملAntistaphylococcal activity of dalbavancin, an experimental glycopeptide.
Dalbavancin, tested against 146 staphylococci, was more potent than other drugs tested, with an MIC at which 50% of staphylococci were inhibited of 0.03 microg/ml and an MIC at which 90% of staphylococci were inhibited of 0.06 microg/ml by microdilution. For all strains, MICs of vancomycin, linezolid, ranbezolid, oritavancin, daptomycin, and quinupristin-dalfopristin were </=4.0 microg/ml. Dalb...
متن کاملDalbavancin, tedizolid phosphate, oritavancin diphosphate, and vedolizumab.
Antibacterial agents Skin and skin structure infections are most often caused by Grampositive bacteria such as streptococci and staphylococci. The number of these infections that are caused by methicillin-resistant Staphylococcus aureus (MRSA) has rapidly increased in recent years in both the community and hospital settings. MRSA skin infections experienced in the community can usually be effec...
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ژورنال
عنوان ژورنال: Canadian journal of health technologies
سال: 2023
ISSN: ['2563-6596']
DOI: https://doi.org/10.51731/cjht.2023.581